Extensive tyrosine nitration in human myocardial inflammation: evidence for the presence of peroxynitrite.

@article{Kooy1997ExtensiveTN,
  title={Extensive tyrosine nitration in human myocardial inflammation: evidence for the presence of peroxynitrite.},
  author={Neil W. Kooy and Stephen J. Lewis and James A. Royall and Y Z Ye and David R. Kelly and Joseph S. Beckman},
  journal={Critical care medicine},
  year={1997},
  volume={25 5},
  pages={
          812-9
        }
}
OBJECTIVES Production of nitric oxide via the cytokine-mediated activation of myocardial inducible nitric oxide synthase decreases myocardial contractility. Whether myocardial dysfunction is mediated directly by nitric oxide or indirectly through the formation of secondary reaction products, such as peroxynitrite, has not been established. Peroxynitrite, but not nitric oxide, reacts with the phenolic ring of tyrosine to form the stable product 3-nitro-L-tyrosine. Demonstration of tissue… Expand
Peroxynitrite is a major contributor to cytokine-induced myocardial contractile failure.
TLDR
It is hypothesized that peroxynitrite itself is responsible for cytokine-induced cardiac depression, and stimulated the concerted enhancement in superoxide and NO-generating activities in the heart, thereby enhancing peroxlynitrite generation, which causes myocardial contractile failure. Expand
Biochemistry of protein tyrosine nitration in cardiovascular pathology.
TLDR
Nitration of tyrosine can affect protein function, which could directly link nitroxidative stress to the molecular alterations found in disease and pharmacological strategies directed towards inhibiting protein nitration will help shed light on the relevance of this post-translational modification to human cardiovascular pathology. Expand
Temporal patterns of tyrosine nitration in embryo heart development.
TLDR
Analysis of tryptic peptides by MALDI-TOF showed that nitration occurs in actin, myosin, and the mitochondrial ATP synthase α chain, suggesting that reactive nitrogen species are not restricted to pathological conditions but may play a role during normal embryonic development. Expand
Peroxynitrite induced nitration and inactivation of myofibrillar creatine kinase in experimental heart failure.
TLDR
These data demonstrate that cardiac ONOO(-) formation and perturbation of myofibrillar energetic controllers occur during experimental heart failure; MM-CK may be a critical cellular target in this setting. Expand
Mechanism of vasculitis and aneurysms in Kawasaki disease: role of nitric oxide.
TLDR
Evidence is supplied that NO through its reactive product, peroxynitrite, and its antigen/tissue marker, nitrotyrosine is directly involved in coronary arteritis and aneurysm development in mice models of Kawasaki disease (KD). Expand
Nitric oxide, peroxynitrite and matrix metalloproteinases: Insight into the pathogenesis of sepsis
TLDR
This review provides an overview of the cardiovascular abnormalities of sepsis as well as various mechanisms of its pathogenicity, with particular emphasis on matrix metalloproteinases. Expand
Protein Nitration in Cardiovascular Diseases
TLDR
The goal of this review is to attract more attention to identification of specific proteins, which undergo tyrosine nitration and to study a correlation between their altered function and pathology. Expand
Role of the peroxynitrite-poly(ADP-ribose) polymerase pathway in human disease.
TLDR
This review focuses on the human data available on the pathophysiological relevance of the peroxynitrite-PARP pathway in a wide range of disparate diseases, ranging from myocardial ischemia/reperfusion injury, myocarditis, heart failure, circulatory shock, and diabetic complications to atherosclerosis, arthritis, colitis, and neurodegenerative disorders. Expand
Nitric Oxide-dependent Generation of Reactive Species in Sickle Cell Disease
TLDR
It is observed that the hemoglobin point mutation of sickle cell disease that mediates hemoglobin polymerization defects is translated, via inflammatory oxidant reactions, into defective cytoskeletal polymerization. Expand
Increased Circulating Levels of 3-Nitrotyrosine Autoantibodies: Marker for or Maker of Cardiovascular Disease?
TLDR
Under physiological conditions, the vascular integrity is mainly guaranteed by nitric oxide (•NO) and prostacyclin (PGI2), causing vasodilation, antiaggregation, anti-inflammation, and intact endothelial barrier function. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 40 REFERENCES
Extensive nitration of protein tyrosines in human atherosclerosis detected by immunohistochemistry.
TLDR
The presence of nitrotyrosine indicates that oxidants derived from nitric oxide such as peroxynitrite are generated in human atherosclerosis and may be involved in its pathogenesis. Expand
Evidence for in vivo peroxynitrite production in human acute lung injury.
TLDR
It is demonstrated that nitrogen-derived oxidants are formed in human acute lung injury and suggested that peroxynitrite may be an important oxidant in inflammatory lung disease. Expand
Pathological implications of nitric oxide, superoxide and peroxynitrite formation.
TLDR
An astonishing variety of tissues synthesize nitric oxide, which has important roles in the control of systemic blood pressure, respiration, digestion, penile erection, platelet aggregation, cerebral blood flow and neuronal synaptic plasticity. Expand
Role of inducible nitric oxide synthase expression and peroxynitrite formation in guinea pig ileitis.
TLDR
The colocalization of tyrosine nitration with iNOS immunoreactivity suggests that inducible NO synthase may be responsible for tissue injury and the formation of NO-dependent nitrating species, potentially peroxynitrite. Expand
Activation of the inducible form of nitric oxide synthase in the brains of patients with multiple sclerosis.
TLDR
It is demonstrated that iNOS, one of the enzymes responsible for the production of NO, is expressed at significant levels in the brains of patients with MS and may contribute to the pathology associated with the disease. Expand
Agonist-induced peroxynitrite production from endothelial cells.
  • N. Kooy, J. Royall
  • Chemistry, Medicine
  • Archives of biochemistry and biophysics
  • 1994
TLDR
Results are consistent with agonist-induced peroxynitrite production by endothelial cells and suggests that peroxysitrite may have an important role in oxidant-induced endothelial injury. Expand
Production of nitric oxide and peroxynitrite in the lung during acute endotoxemia
TLDR
It is demonstrated that AMs and IMs are activated following acute endotoxemia to produce reactive nitrogen intermediates and that both cell types contribute to inflammatory responses in the lung. Expand
Endotoxin triggers the expression of an inducible isoform of nitric oxide synthase and the formation of peroxynitrite in the rat aorta in vivo
TLDR
The demonstration of the in vivo formation of peroxynitrite at sites of ·NO overproduction may necessitate the development of novel and additional approaches for limiting or preventing ·NO‐related cytotoxic or vasodilatory actions during circulatory shock. Expand
Evidence for nitric oxide‐mediated oxidative damage in chronic inflammation Nitrotyrosine in serum and synovial fluid from rheumatoid patients
TLDR
Evidence that NO• plays a role in joint damage in rheumatoid arthritis is evidence that nitro‐aromatics may be ‘markers’ of NO•‐dependent oxidative damage. Expand
Peroxynitrite formation from macrophage-derived nitric oxide.
TLDR
The formation of a relatively long lived, strong oxidant from the reaction of nitric oxide and superoxide in activated macrophages may contribute to inflammatory cell-mediated tissue injury. Expand
...
1
2
3
4
...