Extensive translation of small Open Reading Frames revealed by Poly-Ribo-Seq

@inproceedings{Aspden2014ExtensiveTO,
  title={Extensive translation of small Open Reading Frames revealed by Poly-Ribo-Seq},
  author={Julie L. Aspden and Ying Chen Eyre-Walker and Rose J Phillips and Unum Amin and Muhammad Ali S Mumtaz and Mich{\`e}le Brocard and Juan-Pablo Couso},
  booktitle={eLife},
  year={2014}
}
Thousands of small Open Reading Frames (smORFs) with the potential to encode small peptides of fewer than 100 amino acids exist in our genomes. However, the number of smORFs actually translated, and their molecular and functional roles are still unclear. In this study, we present a genome-wide assessment of smORF translation by ribosomal profiling of polysomal fractions in Drosophila. We detect two types of smORFs bound by multiple ribosomes and thus undergoing productive translation. The… CONTINUE READING
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