Extensive studies on perfusion method plus intra-bone marrow-bone marrow transplantation using cynomolgus monkeys.


The collection of bone marrow cells (BMCs) using a perfusion method has been advantageous not only because of the low contamination of BMCs with T cells from the peripheral blood but also the enrichment of stromal cells, which support hemopoiesis. Before the application of this new method to humans, its safety needed to be confirmed using cynomolgus monkeys… (More)