Extensive nitration of protein tyrosines in human atherosclerosis detected by immunohistochemistry.

@article{Beckmann1994ExtensiveNO,
  title={Extensive nitration of protein tyrosines in human atherosclerosis detected by immunohistochemistry.},
  author={Jacqui S Beckmann and Yu Zhen Ye and Peter G. Anderson and Jiyun Chen and Mary Ann Accavitti and Margaret M Tarpey and Charles R. White},
  journal={Biological chemistry Hoppe-Seyler},
  year={1994},
  volume={375 2},
  pages={81-8}
}
Oxidation of lipoproteins is important for the initiation and propagation of the atherosclerotic lesion and may involve secondary oxidants derived from nitric oxide. Nitric oxide (NO) reacts at near diffusion limited rates with superoxide (O2-.) to form the strong oxidant, peroxynitrite (ONOO-). Nitration on the ortho position of tyrosine is a major product of peroxynitrite attack on proteins. Nitrotyrosine was detected in atherosclerotic lesions of formalin-fixed human coronary arteries with… CONTINUE READING

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