Extensive major histocompatibility complex class I binding promiscuity for Mycobacterium tuberculosis TB10.4 peptides and immune dominance of human leucocyte antigen (HLA)-B*0702 and HLA-B*0801 alleles in TB10.4 CD8 T-cell responses.

@article{AxelssonRobertson2010ExtensiveMH,
  title={Extensive major histocompatibility complex class I binding promiscuity for Mycobacterium tuberculosis TB10.4 peptides and immune dominance of human leucocyte antigen (HLA)-B*0702 and HLA-B*0801 alleles in TB10.4 CD8 T-cell responses.},
  author={Rebecca Axelsson-Robertson and Frank F. Weichold and Donata Sizemore and Markus Wulf and Yasir A. W. Skeiky and Jerry Sadoff and Markus J. Maeurer},
  journal={Immunology},
  year={2010},
  volume={129 4},
  pages={496-505}
}
The molecular definition of major histocompatibility complex (MHC) class I-presented CD8(+) T-cell epitopes from clinically relevant Mycobacterium tuberculosis (Mtb) target proteins will aid in the rational design of T-cell-based diagnostics of tuberculosis (TB) and the measurement of TB vaccine-take. We used an epitope discovery system, based on recombinant MHC class I molecules that cover the most frequent Caucasian alleles [human leucocyte antigen (HLA)-A*0101, A*0201, A*0301, A*1101, A*2402… CONTINUE READING
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We used an epitope discovery system , based on recombinant MHC class I molecules that cover the most frequent Caucasian alleles [ human leucocyte antigen ( HLA)-A*0101 , A*0201 , A*0301 , A*1101 , A*2402 , B*0702 , B*0801 and B*1501 ] , to identify MHC class I - binding peptides from overlapping 9-mer peptides representing the Mtb protein TB10.4 .
We used an epitope discovery system , based on recombinant MHC class I molecules that cover the most frequent Caucasian alleles [ human leucocyte antigen ( HLA)-A*0101 , A*0201 , A*0301 , A*1101 , A*2402 , B*0702 , B*0801 and B*1501 ] , to identify MHC class I - binding peptides from overlapping 9-mer peptides representing the Mtb protein TB10.4 .
HLA - B alleles served as the dominant MHC class I restricting molecules for anti - Mtb TB10.4-specific CD8(+ ) T - cell responses measured in CD8(+ ) T cells from patients with pulmonary TB .
Binding of individual peptides or closely related peptide species to different MHC class I alleles was frequently observed .
HLA - B alleles served as the dominant MHC class I restricting molecules for anti - Mtb TB10.4-specific CD8(+ ) T - cell responses measured in CD8(+ ) T cells from patients with pulmonary TB .
Binding of individual peptides or closely related peptide species to different MHC class I alleles was frequently observed .
We used an epitope discovery system , based on recombinant MHC class I molecules that cover the most frequent Caucasian alleles [ human leucocyte antigen ( HLA)-A*0101 , A*0201 , A*0301 , A*1101 , A*2402 , B*0702 , B*0801 and B*1501 ] , to identify MHC class I - binding peptides from overlapping 9-mer peptides representing the Mtb protein TB10.4 .
We used an epitope discovery system , based on recombinant MHC class I molecules that cover the most frequent Caucasian alleles [ human leucocyte antigen ( HLA)-A*0101 , A*0201 , A*0301 , A*1101 , A*2402 , B*0702 , B*0801 and B*1501 ] , to identify MHC class I - binding peptides from overlapping 9-mer peptides representing the Mtb protein TB10.4 .
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