Extensive linkage disequilibrium, a common 16.7-kilobase deletion, and evidence of balancing selection in the human protocadherin alpha cluster.

@article{Noonan2003ExtensiveLD,
  title={Extensive linkage disequilibrium, a common 16.7-kilobase deletion, and evidence of balancing selection in the human protocadherin alpha cluster.},
  author={James P Noonan and Jun Li and Loan Nguyen and Chenier Caoile and Mark Dickson and Gerald A Tuskan and Jeremy Schmutz and Marcus W. Feldman and Richard M. Myers},
  journal={American journal of human genetics},
  year={2003},
  volume={72 3},
  pages={621-35}
}
Regions of extensive linkage disequilibrium (LD) appear to be a common feature of the human genome. However, the mechanisms that maintain these regions are unknown. In an effort to understand whether gene density contributes to LD, we determined the degree of promoter sequence variation in a large tandem-arrayed gene family, the human protocadherin alpha cluster, on chromosome 5. These genes are expressed at synaptic junctions in the developing brain and the adult brain and may be involved in… CONTINUE READING
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