Extensive intestinal first-pass elimination and predominant hepatic distribution of berberine explain its low plasma levels in rats.

@article{Liu2010ExtensiveIF,
  title={Extensive intestinal first-pass elimination and predominant hepatic distribution of berberine explain its low plasma levels in rats.},
  author={Yi-tong Liu and Haiping Hao and Hong-Guang Xie and Li Sa Lai and Qiong Wang and Changxiao Liu and Guang-ji Wang},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2010},
  volume={38 10},
  pages={1779-84}
}
Berberine, one of the most commonly used natural products, exhibits a poor plasma concentration-effect relationship whose underlying mechanisms remain largely unclear. This study was designed to test the hypothesis that extensive first-pass elimination and abundant tissue distribution of berberine may be its specific pharmacokinetic properties. For that, four different dosing routes, intragastric, intraduodenal, intraportal, and intravenous, were used to investigate the gastric, intestinal, and… CONTINUE READING

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