Extensive interbreed, but minimal intrabreed, variation of DLA class II alleles and haplotypes in dogs.

@article{Kennedy2002ExtensiveIB,
  title={Extensive interbreed, but minimal intrabreed, variation of DLA class II alleles and haplotypes in dogs.},
  author={Lorna J. Kennedy and Annette Barnes and George M. Happ and Rupert J. Quinnell and David W. Bennett and John M Angles and Michael Joseph Day and Nick Carmichael and John F. Innes and Diana Isherwood and Stuart D. Carter and Wendy Thomson and William E. R. Ollier},
  journal={Tissue antigens},
  year={2002},
  volume={59 3},
  pages={
          194-204
        }
}
The DLA class II genes in the dog major histocompatibility complex are highly polymorphic. To date, 52 DLA-DRB1, 16 DLA-DQA1 and 41 DLA-DQB1 allelic sequences have been assigned. The aim of this study was to examine the intrabreed and interbreed variation of DLA allele and haplotype frequencies in dogs, and to ascertain whether conserved DLA class II haplotypes occur within and between different breeds. One thousand and 25 DNA samples from over 80 different breeds were DLA class II genotyped… CONTINUE READING

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