Extensive genomic duplication during early chordate evolution

@article{McLysaght2002ExtensiveGD,
  title={Extensive genomic duplication during early chordate evolution},
  author={Aoife McLysaght and Karsten Hokamp and Kenneth H. Wolfe},
  journal={Nature Genetics},
  year={2002},
  volume={31},
  pages={200-204}
}
Opinions on the hypothesis that ancient genome duplications contributed to the vertebrate genome range from strong skepticism to strong credence. Previous studies concentrated on small numbers of gene families or chromosomal regions that might not have been representative of the whole genome, or used subjective methods to identify paralogous genes and regions. Here we report a systematic and objective analysis of the draft human genome sequence to identify paralogous chromosomal regions… 

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