Extensive genetic polymorphism in the human tumor necrosis factor region and relation to extended HLA haplotypes.

@article{Jongeneel1991ExtensiveGP,
  title={Extensive genetic polymorphism in the human tumor necrosis factor region and relation to extended HLA haplotypes.},
  author={C. Victor Jongeneel and Laurence Briant and Irina A Udalova and Andr{\'e} Sevin and Sergei A. Nedospasov and Anne Cambon-Thomsen},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1991},
  volume={88 21},
  pages={9717-21}
}
We have identified three polymorphic microsatellites (which we call TNFa, TNFb, and TNFc) within a 12-kilobase region of the human major histocompatibility complex (MHC) that includes the tumor necrosis factor (TNF) locus. TNFc is located within the first intron of the TNF-beta gene and has only 2 alleles. TNFa and TNFb are 3.5 kilobases upstream (telomeric) of the TNF-beta gene and have at least 13 and 7 alleles, respectively. TNFa, -b, and -c alleles are in linkage disequilibrium with alleles… CONTINUE READING
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