Extensive functional overlap between sigma factors in Escherichia coli.

  title={Extensive functional overlap between sigma factors in Escherichia coli.},
  author={Joseph T Wade and Daniel Castro Roa and David C Grainger and Douglas Hurd and Stephen J W Busby and Kevin Struhl and Vladimir Svetlov},
  journal={Nature structural & molecular biology},
  volume={13 9},
Bacterial core RNA polymerase (RNAP) must associate with a sigma factor to recognize promoter sequences. Escherichia coli encodes seven sigma factors, each believed to be specific for a largely distinct subset of promoters. Using microarrays representing the entire E. coli genome, we identify 87 in vivo targets of sigma32, the heat-shock sigma factor, and estimate that there are 120-150 sigma32 promoters in total. Unexpectedly, 25% of these sigma32 targets are located within coding regions… CONTINUE READING

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