Extensive editing of a small fraction of human T-cell leukemia virus type 1 genomes by four APOBEC3 cytidine deaminases.

@article{Mahieux2005ExtensiveEO,
  title={Extensive editing of a small fraction of human T-cell leukemia virus type 1 genomes by four APOBEC3 cytidine deaminases.},
  author={Renaud Mahieux and Rodolphe Susp{\`e}ne and Fr{\'e}d{\'e}ric Delebecque and Michel Henry and Olivier Schwartz and Simon Wain-Hobson and J P Vartanian},
  journal={The Journal of general virology},
  year={2005},
  volume={86 Pt 9},
  pages={2489-94}
}
In the absence of the human immunodeficiency virus type 1 (HIV-1) Vif protein, the host-cell cytidine deaminases APOBEC3F and -3G are co-packaged along with virion RNA. Upon infection of target cells, nascent single-stranded DNA can be edited extensively, invariably giving rise to defective genomes called G-->A hypermutants. Although human T-cell leukemia virus type 1 (HTLV-1) replicates in the same cell type as HIV-1, it was shown here that HTLV-1 is relatively resistant to the antiviral… CONTINUE READING

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