Extensive ductal carcinoma In situ with small foci of invasive ductal carcinoma: evidence of genetic resemblance by CGH.

@article{Aubele2000ExtensiveDC,
  title={Extensive ductal carcinoma In situ with small foci of invasive ductal carcinoma: evidence of genetic resemblance by CGH.},
  author={Michaela Aubele and Anita Mattis and Horst F. Zitzelsberger and Axel Walch and Markus Kremer and Gerhard Welzl and Heinz Hoefler and Martin Werner},
  journal={International journal of cancer},
  year={2000},
  volume={85 1},
  pages={82-6}
}
Although ductal carcinoma in situ (DCIS) of the breast is accepted as a potential precursor lesion for invasive ductal cancer (IDC), the critical genetic events associated with the tumor progression remain unknown. Since some extensive DCIS may show a small focus of IDC, these cases seem to be particularly suitable to investigate the primary abnormalities that determine the progression from in situ to early invasive cancer. We combined laser-microdissection with degenerative oligonucleotide… CONTINUE READING