Extensive double humanization of both liver and hematopoiesis in FRGN mice.

Abstract

Preclinical research in animals often fails to adequately predict the outcomes observed in human patients. Chimeric animals bearing individual human tissues have been developed to provide improved models of human-specific cellular processes. Mice transplanted with human hematopoietic stem cells can be used to study human immune responses, infections of… (More)
DOI: 10.1016/j.scr.2014.08.006

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