Extensive cross-reactive neutralizing antibody response in Indian patients with limited genetic diversity of HIV-1.

@article{Lakhashe2007ExtensiveCN,
  title={Extensive cross-reactive neutralizing antibody response in Indian patients with limited genetic diversity of HIV-1.},
  author={Samir K. Lakhashe and Smita Kulkarni and Madhuri Rajeev Thakar and Manisha V Ghate and Ramesh Shivram Paranjape},
  journal={Virology},
  year={2007},
  volume={359 2},
  pages={295-301}
}
Genome sequence analysis of HIV-1 subtype C viruses from India shows monophyletic lineage and relatively limited genetic diversity. To understand its immunological implication, cross-reactivity of neutralizing antibody response was investigated. In primary screening, neutralizing antibody response to single heterologous primary HIV-1 subtype C isolate was assessed in plasma samples from 235 HIV-1 infected, anti-retroviral treatment naive individuals from Pune, India. Plasma samples that showed… CONTINUE READING
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