Extensive clear zone and defective ruffled border formation in osteoclasts of osteopetrotic (ia/ia) rats: implications for secretory function.

@article{Reinholt1999ExtensiveCZ,
  title={Extensive clear zone and defective ruffled border formation in osteoclasts of osteopetrotic (ia/ia) rats: implications for secretory function.},
  author={Finn Per Reinholt and Kjell R Hultenby and Dick Heineg{\aa}rd and Sandy C. Marks and Maria Norg{\aa}rd and G{\"u}ls{\"u}m Anderson},
  journal={Experimental cell research},
  year={1999},
  volume={251 2},
  pages={477-91}
}
The cellular distribution of osteoclast integrin subunits alpha(v) and beta(3), the tissue distribution, and level of the apparent ligand osteopontin (OPN) as well as of the putative regulatory enzyme tartrate-resistant acid phosphatase (TRAP) were studied along with the intracellular distribution of the activation marker c-src in osteopetrotic ia/ia (incisors-absent) mutant rats and their normal littermates. In ia/ia rats, the osteoclasts are incapable of bone matrix resorption… CONTINUE READING