Extensive chromatin remodelling and establishment of transcription factor 'hotspots' during early adipogenesis.

@article{Siersbk2011ExtensiveCR,
  title={Extensive chromatin remodelling and establishment of transcription factor 'hotspots' during early adipogenesis.},
  author={Rasmus Siersb{\ae}k and Ronni Nielsen and S Rose John and Myong-Hee Sung and Songjoon Baek and Anne Loft and Gordon L. Hager and S Mandrup},
  journal={The EMBO journal},
  year={2011},
  volume={30 8},
  pages={1459-72}
}
Adipogenesis is tightly controlled by a complex network of transcription factors acting at different stages of differentiation. Peroxisome proliferator-activated receptor γ (PPARγ) and CCAAT/enhancer-binding protein (C/EBP) family members are key regulators of this process. We have employed DNase I hypersensitive site analysis to investigate the genome-wide changes in chromatin structure that accompany the binding of adipogenic transcription factors. These analyses revealed a dramatic and… CONTINUE READING
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