Extensive analysis of the 7q31 region in human prostate tumors supports TES as the best candidate tumor suppressor gene.

@article{Chne2004ExtensiveAO,
  title={Extensive analysis of the 7q31 region in human prostate tumors supports TES as the best candidate tumor suppressor gene.},
  author={Laurent Ch{\^e}ne and Christiane Giroud and François Desgrandchamps and Laurent Boccon-Gibod and Olivier Cussenot and Philippe Berthon and Alain Latil},
  journal={International journal of cancer},
  year={2004},
  volume={111 5},
  pages={798-804}
}
Loss of heterozygosity (LOH) on chromosome arm 7q31 is found in many prostate tumors. Such alterations are generally associated with inactivation of tumor suppressor genes. It has been shown previously that the main region of LOH at 7q31 spans the interval between the D7S486 and D7S2460 microsatellite loci, which contains several candidate tumor suppressor genes (TSG) such as TES, CAV2, CAV1, MET, CAPZA2, ST7 and WNT2. We tested 41 human sporadic prostate tumors for 7q31 LOH by using 5… CONTINUE READING