Extensive amplification and self-renewal of human primitive hematopoietic stem cells from cord blood.

@article{Piacibello1997ExtensiveAA,
  title={Extensive amplification and self-renewal of human primitive hematopoietic stem cells from cord blood.},
  author={Wanda Piacibello and Fiorella Sanavio and Lucia Garetto and Antonella Severino and Donato Bergandi and Jacopo Ferrario and Franca Fagioli and Mitchel Berger and Massimo Aglietta},
  journal={Blood},
  year={1997},
  volume={89 8},
  pages={
          2644-53
        }
}
The use of umbilical cord blood as a source of marrow repopulating cells for the treatment of pediatric malignancies has been established. Given the general availability, the ease of procurement, and progenitor content, cord blood is an attractive alternative to bone marrow or growth factor mobilized peripheral blood cells as a source of transplantable hematopoietic tissue. However, there is a major potential limitation to the widespread use of cord blood as a source of hematopoietic stem cells… CONTINUE READING

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