Extensive White Matter Alterations and Its Correlations with Ataxia Severity in SCA 2 Patients

@inproceedings{HernandezCastillo2015ExtensiveWM,
  title={Extensive White Matter Alterations and Its Correlations with Ataxia Severity in SCA 2 Patients},
  author={Carlos R Hernandez-Castillo and V{\'i}ctor Galvez and Roberto Emmanuele Mercadillo and Rosalinda D{\'i}az and Aurelio Campos-Romo and Juan Fern{\'a}ndez-Ruiz and Johannes Boltze},
  booktitle={PloS one},
  year={2015}
}
BACKGROUND Previous studies of SCA2 have revealed significant degeneration of white matter tracts in cerebellar and cerebral regions. The motor deficit in these patients may be attributable to the degradation of projection fibers associated with the underlying neurodegenerative process. However, this relationship remains unclear. Statistical analysis of diffusion tensor imaging enables an unbiased whole-brain quantitative comparison of the diffusion proprieties of white matter tracts in vivo… CONTINUE READING