Extensive Transcriptional Regulation of Chromatin Modifiers during Human Neurodevelopment

  title={Extensive Transcriptional Regulation of Chromatin Modifiers during Human Neurodevelopment},
  author={Matthias Karl Weng and Bastian Zimmer and Dominik P{\"o}ltl and Marc P. Broeg and Violeta N. Ivanova and John Antonydas Gaspar and Agapios Sachinidis and U. W{\"u}llner and Tanja Waldmann and Marcel Leist},
  booktitle={PloS one},
Epigenetic changes, including histone modifications or chromatin remodeling are regulated by a large number of human genes. We developed a strategy to study the coordinate regulation of such genes, and to compare different cell populations or tissues. A set of 150 genes, comprising different classes of epigenetic modifiers was compiled. This new tool was used initially to characterize changes during the differentiation of human embryonic stem cells (hESC) to central nervous system neuroectoderm… CONTINUE READING


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