Extensive Hidden Genomic Mosaicism Revealed in Normal Tissue.

@article{Vattathil2016ExtensiveHG,
  title={Extensive Hidden Genomic Mosaicism Revealed in Normal Tissue.},
  author={Selina Vattathil and Paul Scheet},
  journal={American journal of human genetics},
  year={2016},
  volume={98 3},
  pages={571-578}
}
Genomic mosaicism arising from post-zygotic mutation has recently been demonstrated to occur in normal tissue of individuals ascertained with varied phenotypes, indicating that detectable mosaicism may be less an exception than a rule in the general population. A challenge to comprehensive cataloging of mosaic mutations and their consequences is the presence of heterogeneous mixtures of cells, rendering low-frequency clones difficult to discern. Here we applied a computational method using… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 25 times. VIEW TWEETS

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-8 of 8 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 21 references

Similar Papers

Loading similar papers…