Extensive Hidden Genomic Mosaicism Revealed in Normal Tissue.

  title={Extensive Hidden Genomic Mosaicism Revealed in Normal Tissue.},
  author={Selina Vattathil and Paul Scheet},
  journal={American journal of human genetics},
  volume={98 3},
Genomic mosaicism arising from post-zygotic mutation has recently been demonstrated to occur in normal tissue of individuals ascertained with varied phenotypes, indicating that detectable mosaicism may be less an exception than a rule in the general population. A challenge to comprehensive cataloging of mosaic mutations and their consequences is the presence of heterogeneous mixtures of cells, rendering low-frequency clones difficult to discern. Here we applied a computational method using… CONTINUE READING
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