Extensive HLA class II studies in 58 non-DRB1*15 (DR2) narcoleptic patients with cataplexy.

@article{Mignot1997ExtensiveHC,
  title={Extensive HLA class II studies in 58 non-DRB1*15 (DR2) narcoleptic patients with cataplexy.},
  author={Emmanuel Mignot and Akinori Kimura and A. Lattermann and Xingyu Lin and Sachie Yasunaga and Gertrud Mueller-Eckhardt and C. Rattazzi and Li Lin and Christian Guilleminault and F. Carl Grumet and Gillian Mayer and William C. Dement and Peter Underhill},
  journal={Tissue antigens},
  year={1997},
  volume={49 4},
  pages={329-41}
}
Narcolepsy is a sleep disorder that has been shown to be tightly associated with HLA DR15 (DR2). In this study, 58 non-DR15 patients with narcolepsy-cataplexy were typed at the HLA DRB1, DQA1 and DQB1 loci. Subjects included both sporadic cases and narcoleptic probands from multiplex families. Additional markers studied in the class II region were the promoters of the DQA1 and DQB1 genes, two CA repeat polymorphisms (DQCAR and DQCARII) located between the DQA1 and DQB1 genes, three CA repeat… CONTINUE READING

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