Extensive HIV-1 Intra-Host Recombination Is Common in Tissues with Abnormal Histopathology

@article{Lamers2009ExtensiveHI,
  title={Extensive HIV-1 Intra-Host Recombination Is Common in Tissues with Abnormal Histopathology},
  author={Susanna L. Lamers and Marco Salemi and Derek C. Galligan and Tulio de Oliveira and Gary B. Fogel and Sara C. Granier and Lu Zhao and Joseph N. Brown and Alanna Morris and Eliezer Masliah and Michael S. McGrath},
  journal={PLoS ONE},
  year={2009},
  volume={4},
  pages={5087 - 5094}
}
There is evidence that immune-activated macrophages infected with the Human Immunodeficiency Virus (HIV) are associated with tissue damage and serve as a long-lived viral reservoir during therapy. In this study, we analyzed 780 HIV genetic sequences generated from 53 tissues displaying normal and abnormal histopathology. We found up to 50% of the sequences from abnormal lymphoid and macrophage rich non-lymphoid tissues were intra-host viral recombinants. The presence of extensive recombination… CONTINUE READING

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