Extensive Genome-Wide Variability of Human Cytomegalovirus in Congenitally Infected Infants

  title={Extensive Genome-Wide Variability of Human Cytomegalovirus in Congenitally Infected Infants},
  author={Nicholas Renzette and Bornali Bhattacharjee and Jeffrey D Jensen and Laura Gibson and Timothy F. Kowalik},
  booktitle={PLoS pathogens},
Research has shown that RNA virus populations are highly variable, most likely due to low fidelity replication of RNA genomes. It is generally assumed that populations of DNA viruses will be less complex and show reduced variability when compared to RNA viruses. Here, we describe the use of high throughput sequencing for a genome wide study of viral populations from urine samples of neonates with congenital human cytomegalovirus (HCMV) infections. We show that HCMV intrahost genomic variability… CONTINUE READING

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