Extensive Gene Traffic on the Mammalian X Chromosome

@article{Emerson2004ExtensiveGT,
  title={Extensive Gene Traffic on the Mammalian X Chromosome},
  author={J J Emerson and Henrik Kaessmann and Esther Betr{\'a}n and Manyuan Long},
  journal={Science},
  year={2004},
  volume={303},
  pages={537 - 540}
}
Mammalian sex chromosomes have undergone profound changes since evolving from ancestral autosomes. By examining retroposed genes in the human and mouse genomes, we demonstrate that, during evolution, the mammalian X chromosome has generated and recruited a disproportionately high number of functional retroposed genes, whereas the autosomes experienced lower gene turnover. Most autosomal copies originating from X-linked genes exhibited testis-biased expression. Such export is incompatible with… 
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