Extensive Editing of mRNAs for the Squid Delayed Rectifier K+ Channel Regulates Subunit Tetramerization

@article{Rosenthal2002ExtensiveEO,
  title={Extensive Editing of mRNAs for the Squid Delayed Rectifier K+ Channel Regulates Subunit Tetramerization},
  author={Joshua J C Rosenthal and Francisco Bezanilla},
  journal={Neuron},
  year={2002},
  volume={34},
  pages={743-757}
}
We report the extensive editing of mRNAs that encode the classical delayed rectifier K+ channel (SqK(v)1.1A) in the squid giant axon. Using a quantitative RNA editing assay, 14 adenosine to guanine transitions were identified, and editing efficiency varied tremendously between positions. Interestingly, half of the sites are targeted to the T1 domain, important for subunit assembly. Other sites occur in the channel's transmembrane spans. The effects of editing on K+ channel function are… CONTINUE READING

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