Extensive DNA mimicry by the ArdA anti-restriction protein and its role in the spread of antibiotic resistance

@inproceedings{McMahon2009ExtensiveDM,
  title={Extensive DNA mimicry by the ArdA anti-restriction protein and its role in the spread of antibiotic resistance},
  author={Stephen A. McMahon and G. A. Roberts and K A Johnson and Laurie P. Cooper and Huanting Liu and J. A. Henton White and Lester G. Carter and Bansi Sanghvi and Muse Oke and Malcolm D. Walkinshaw and Garry W. Blakely and James H. Naismith and David T. F. Dryden},
  booktitle={Nucleic acids research},
  year={2009}
}
The ardA gene, found in many prokaryotes including important pathogenic species, allows associated mobile genetic elements to evade the ubiquitous Type I DNA restriction systems and thereby assist the spread of resistance genes in bacterial populations. As such, ardA contributes to a major healthcare problem. We have solved the structure of the ArdA protein from the conjugative transposon Tn916 and find that it has a novel extremely elongated curved cylindrical structure with defined helical… CONTINUE READING

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