Extensive Changes in the Expression of the Opioid Genes between Humans and Chimpanzees

@article{CruzGordillo2010ExtensiveCI,
  title={Extensive Changes in the Expression of the Opioid Genes between Humans and Chimpanzees},
  author={Peter Cruz-Gordillo and Olivier Fedrigo and Gregory A. Wray and Courtney C. Babbitt},
  journal={Brain, Behavior and Evolution},
  year={2010},
  volume={76},
  pages={154 - 162}
}
The various means by which the body perceives, transmits, and resolves the experiences of pain and nociception are mediated by a host of molecules, including neuropeptides within the opioid gene signaling pathway. The peptide ligands and receptors encoded by this group of genes have been linked to behavioral disorders as well as a number of psychiatric affective disorders. Our aim was to explore the recent evolutionary history of these two gene families by taking a comparative genomics approach… 
Analysis of synaptic gene expression in the neocortex of primates reveals evolutionary changes in glutamatergic neurotransmission.
TLDR
There have been significant changes during primate brain evolution in the components of the glutamatergic signaling pathway in terms of gene expression, protein expression, and promoter sequence changes, which could entail functional modifications in the regulation of specific genes related to processes underlying learning and memory.
The genetics of the opioid system and specific drug addictions
TLDR
The genetics of the major genes of the opioid system (opioid receptors and their endogenous ligands) in connection to addiction to opioids, cocaine, alcohol and methamphetamines are described.
Physiology, signaling, and pharmacology of opioid receptors and their ligands in the gastrointestinal tract: current concepts and future perspectives
TLDR
The opportunities of targeting the opioid system are discussed, suggesting future treatment options for functional disorders and inflammatory states of the GI tract.
Toward a Deeper Understanding of the Genetics of Bipolar Disorder
  • B. Kerner
  • Biology, Medicine
    Front. Psychiatry
  • 2015
TLDR
Recently, the group has published data which supported an oligogenic genetic model of transmission in a family with bipolar disorder, in this family, three affected siblings shared rare, damaging mutations in multiple genes, which were linked to stress response pathways.
Genetic correlates of the evolving primate brain.
  • E. Vallender
  • Biology, Medicine
    Progress in brain research
  • 2012
TLDR
This chapter focuses on understanding the genetic basis of primate brain evolution, considering the substrates and mechanisms through which genetic change occurs and the implications that the current understandings and tools have for what is already discovered and where the studies will head in the future.
Endogenous opiates and behavior: 2010
This paper is the thirty-third consecutive installment of the annual review of research concerning the endogenous opioid system. It summarizes papers published during 2010 that studied the behavioral
Multiple Genomic Events Altering Hominin SIGLEC Biology and Innate Immunity Predated the Common Ancestor of Humans and Archaic Hominins
TLDR
The data suggest that innate immune interactions with pathogens markedly altered hominin Siglec biology between 0.6 and 2 Ma, potentially affecting human evolution.
Elevated OPRD1 promoter methylation in Alzheimer’s disease patients
TLDR
The results suggest that OPRD1 promoter hypermethylation is associated with the risk of AD.
Evolution of Nervous Systems
This chapter starts by discussing the question of what type of organisms can be happy, concluding that it rests with the capacity to experience feelings, which also implies a capacity for
Genomic and Personalized Medicine Approaches for Substance Use Disorders (SUDs) Looking at Genome-Wide Association Studies
TLDR
The state-of-the-art genomics and pharmacogenomics of SUDs, and the possible future perspectives related to medical treatment response in people that ask for assistance in solving drug-related problems are reported.
...
1
2
...

References

SHOWING 1-10 OF 90 REFERENCES
Concomitant Duplications of Opioid Peptide and Receptor Genes before the Origin of Jawed Vertebrates
TLDR
The system of opioid peptides and receptors was largely formed by the genome doublings that took place early in vertebrate evolution.
Evolution of vertebrate opioid receptors
TLDR
The complete vertebrate opioid system was already established in the first jawed vertebrates about 450 million years ago, and the ancestral receptor gene duplications coincide with the origin of the four opioid peptide precursor genes.
Human Expression Variation in the Mu-Opioid Receptor is Paralleled in Rhesus Macaque
TLDR
A comprehensive survey of naturally occurring polymorphisms in Indian-origin rhesus macaques is performed and three 5′ UTR haplotypes with effects on expression level are identified, which have implications for future studies seeking to model the opioid system and its associated phenotypes in rhesu macaques.
Expansion of the human μ-opioid receptor gene architecture: novel functional variants
TLDR
Evidence is provided for an essential role for MOR-1K isoforms in nociceptive signaling and suggest that genetic variations in alternative OPRM1 isoforms may contribute to individual differences in opiate responses.
Regional patterns of gene expression in human and chimpanzee brains.
TLDR
A subset of genes that show expression differences between humans and chimpanzees are distributed nonrandomly across the genome and are statistically significantly enriched in regions that are recently duplicated in humans.
Analyzing the evolution of the opioid/orphanin gene family.
TLDR
A gene family that illustrates all of these processes and the advantages of combining genomics with proteomics is the opioid/orphanin gene family.
An Allelic Variation in the Human Prodynorphin Gene Promoter Alters Stimulus‐Induced Expression
TLDR
D Dynorphin was found to be involved in many pathophysiological processes so that the described prodynorphin alleles may correlate with the occurrence of several diseases, for example, drug addiction, however, prodynoirin allelic distributions were not significantly different in heroin addicts and control subjects.
Structure, tissue distribution, and chromosomal localization of the prepronociceptin gene.
TLDR
Northern blot analysis shows that the PPNOC gene is predominantly transcribed in the central nervous system (brain and spinal cord) and, albeit weakly, in the ovary, the sole peripheral organ expressing the gene.
Ancient and Recent Positive Selection Transformed Opioid cis-Regulation in Humans
TLDR
It is found that positive natural selection altered the cis-regulation of human prodynorphin, the precursor molecule for a suite of endogenous opioids and neuropeptides with critical roles in regulating perception, behavior, and memory.
Allelic Expression Imbalance of Human mu Opioid Receptor (OPRM1) Caused by Variant A118G*
TLDR
Results indicate that OPRM1-G118 is a functional variant with deleterious effects on both mRNA and protein yield, and clarifying the functional relevance of polymorphisms associated with susceptibility to a complex disorder such as drug addiction provides a foundation for clinical association studies.
...
1
2
3
4
5
...