Extensive Ace2 duplication and multiple mutations on Ace1 and Ace2 are related with high level of organophosphates resistance in Aphis gossypii.

@article{Shang2014ExtensiveAD,
  title={Extensive Ace2 duplication and multiple mutations on Ace1 and Ace2 are related with high level of organophosphates resistance in Aphis gossypii.},
  author={Qingli Shang and Yiou Pan and Kui Fang and Jinghui Xi and Andrew Thomas Wong and James Andrew Brennan and Chuanwang Cao},
  journal={Environmental toxicology},
  year={2014},
  volume={29 5},
  pages={526-33}
}
Aphis gossypii (Glover) has been found to possess multiple mutations in the acetylcholinesterase (AChE) gene (Ace) that might involve target site insensitivity. In vitro functional expression of AChEs reveals that the resistant Ace1 (Ace1R) and Ace2 (Ace2R) were significantly less inhibited by eserine, omethoate, and malaoxon than the susceptible Ace1 (Ace1S) and Ace2 (Ace2S). Furthermore, in both the mutant and susceptible AChEs, Ace2 was significantly less sensitive to eserine, omethoate, and… CONTINUE READING