Extension of variance components approach to incorporate temporal trends and longitudinal pedigree data analysis.

Abstract

Here we present a method that permits one to evaluate genetic effects and to detect genetic linkages by using serial observations of quantitative traits in pedigrees. We developed a statistical method that incorporates longitudinal family data and genetic marker information into an estimating equations framework. With this approach, we can study changes in… (More)

Topics

Cite this paper

@article{Andrade2002ExtensionOV, title={Extension of variance components approach to incorporate temporal trends and longitudinal pedigree data analysis.}, author={Mariza de Andrade and Ren{\'e} Gu{\'e}guen and Sophie Visvikis and Catherine Sass and G{\'e}rard Siest and Christopher I. Amos}, journal={Genetic epidemiology}, year={2002}, volume={22 3}, pages={221-32} }