Extension of the thrombolytic time window with minocycline in experimental stroke.

Abstract

BACKGROUND AND PURPOSE Thrombolysis with tPA is the only FDA-approved therapy for acute ischemic stroke. But its widespread application remains limited by narrow treatment time windows and the related risks of cerebral hemorrhage. In this study, we ask whether minocycline can prevent tPA-associated cerebral hemorrhage and extend the reperfusion window in an… (More)
DOI: 10.1161/STROKEAHA.108.514026

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