Extension of the Lancefield classification for group A streptococci by addition of 22 new M protein gene sequence types from clinical isolates: emm103 to emm124.

@article{Facklam2002ExtensionOT,
  title={Extension of the Lancefield classification for group A streptococci by addition of 22 new M protein gene sequence types from clinical isolates: emm103 to emm124.},
  author={Richard F Facklam and Diana R. Martin and Marguerite Lovgren and Dwight Richard Johnson and Androulla Efstratiou and Terry A Thompson and Sonia Gowan and Paula Kriz and Gregory J. Tyrrell and Edward A Kaplan and Bernard Beall},
  journal={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},
  year={2002},
  volume={34 1},
  pages={28-38}
}
Classic M protein serotyping has been invaluable during the past 60 years for the determination of relationships between different group A streptococci (GAS) strains and the varied clinical manifestations inflicted by these organisms worldwide. Nonetheless, during the past 20 years, the difficulties of continued expansion of the serology-based Lancefield classification scheme for GAS have become increasingly apparent. By use of a less demanding sequence-based methodology that closely adheres to… CONTINUE READING