Extension of life-span with superoxide dismutase/catalase mimetics.
@article{Melov2000ExtensionOL, title={Extension of life-span with superoxide dismutase/catalase mimetics.}, author={Simon Melov and Julia Ravenscroft and S. Malik and Matthew S. Gill and Don W. Walker and Peter E Clayton and Douglas C. Wallace and Bernard Malfroy and Susan R. Doctrow and Gordon J. Lithgow}, journal={Science}, year={2000}, volume={289 5484}, pages={ 1567-9 } }
We tested the theory that reactive oxygen species cause aging. We augmented the natural antioxidant systems of Caenorhabditis elegans with small synthetic superoxide dismutase/catalase mimetics. Treatment of wild-type worms increased their mean life-span by a mean of 44 percent, and treatment of prematurely aging worms resulted in normalization of their life-span (a 67 percent increase). It appears that oxidative stress is a major determinant of life-span and that it can be counteracted by…
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