Extension of life-span with superoxide dismutase/catalase mimetics.

@article{Melov2000ExtensionOL,
  title={Extension of life-span with superoxide dismutase/catalase mimetics.},
  author={Simon Melov and J. Ravenscroft and S. Malik and Matthew S Gill and Don W. Walker and Peter E Clayton and Douglas C. Wallace and Bernard Malfroy and Susan R. Doctrow and Gordon J. Lithgow},
  journal={Science},
  year={2000},
  volume={289 5484},
  pages={
          1567-9
        }
}
We tested the theory that reactive oxygen species cause aging. We augmented the natural antioxidant systems of Caenorhabditis elegans with small synthetic superoxide dismutase/catalase mimetics. Treatment of wild-type worms increased their mean life-span by a mean of 44 percent, and treatment of prematurely aging worms resulted in normalization of their life-span (a 67 percent increase). It appears that oxidative stress is a major determinant of life-span and that it can be counteracted by… Expand
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