Extension of Murine Life Span by Overexpression of Catalase Targeted to Mitochondria

@article{Schriner2005ExtensionOM,
  title={Extension of Murine Life Span by Overexpression of Catalase Targeted to Mitochondria},
  author={S. E. Schriner and N. Linford and G. Martin and P. Treuting and C. Ogburn and M. Emond and P. Coskun and W. Ladiges and N. Wolf and H. Van Remmen and D. Wallace and P. Rabinovitch},
  journal={Science},
  year={2005},
  volume={308},
  pages={1909 - 1911}
}
  • S. E. Schriner, N. Linford, +9 authors P. Rabinovitch
  • Published 2005
  • Biology, Medicine
  • Science
  • To determine the role of reactive oxygen species in mammalian longevity, we generated transgenic mice that overexpress human catalase localized to the peroxisome, the nucleus, or mitochondria (MCAT). Median and maximum life spans were maximally increased (averages of 5 months and 5.5 months, respectively) in MCAT animals. Cardiac pathology and cataract development were delayed, oxidative damage was reduced, H2O2 production and H2O2-induced aconitase inactivation were attenuated, and the… CONTINUE READING
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