Extension of Long Leading Processes and Neuronal Migration in the Mammalian Brain Directed by the Chemoattractant Netrin-1

@article{Yee1999ExtensionOL,
  title={Extension of Long Leading Processes and Neuronal Migration in the Mammalian Brain Directed by the Chemoattractant Netrin-1},
  author={Kathleen T Yee and Horst H. Simon and Marc Tessier-Lavigne and Dennis D. M. O'Leary},
  journal={Neuron},
  year={1999},
  volume={24},
  pages={607-622}
}
Long distance cell migration occurs throughout the developing CNS, but the underlying cellular and molecular mechanisms are poorly understood. We show that the directed circumferential migration of basilar pontine neurons from their origin in the neuroepithelium of the dorsal hindbrain to the ventral midline involves the extension of long (>1 mm) leading processes, which marker analyses suggest are molecularly distinct from axons. In vivo analysis of knockout mice implicates the axonal… CONTINUE READING

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