Extending thrombolysis to 4·5–9 h and wake-up stroke using perfusion imaging: a systematic review and meta-analysis of individual patient data

@article{Campbell2019ExtendingTT,
  title={Extending thrombolysis to 4·5–9 h and wake-up stroke using perfusion imaging: a systematic review and meta-analysis of individual patient data},
  author={B. Campbell and H. Ma and P. Ringleb and M. Parsons and ECASS-4 and Epithet Investigators Extend},
  journal={The Lancet},
  year={2019},
  volume={394},
  pages={139-147}
}
BACKGROUND Stroke thrombolysis with alteplase is currently recommended 0-4·5 h after stroke onset. We aimed to determine whether perfusion imaging can identify patients with salvageable brain tissue with symptoms 4·5 h or more from stroke onset or with symptoms on waking who might benefit from thrombolysis. METHODS In this systematic review and meta-analysis of individual patient data, we searched PubMed for randomised trials published in English between Jan 1, 2006, and March 1, 2019. We… Expand
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