Extending the classification of bacterial transcription factors beyond the helix-turn-helix motif as an alternative approach to discover new cis/trans relationships.

@article{Rigali2004ExtendingTC,
  title={Extending the classification of bacterial transcription factors beyond the helix-turn-helix motif as an alternative approach to discover new cis/trans relationships.},
  author={S{\'e}bastien Rigali and Maximilian Schlicht and Paul A Hoskisson and Harald Nothaft and M. A. Merzbacher and Bernard Joris and Fritz Titgemeyer},
  journal={Nucleic acids research},
  year={2004},
  volume={32 11},
  pages={3418-26}
}
Transcription factors (TFs) of bacterial helix-turn-helix superfamilies exhibit different effector-binding domains (EBDs) fused to a DNA-binding domain with a common feature. In a previous study of the GntR superfamily, we demonstrated that classifying members into subfamilies according to the EBD heterogeneity highlighted unsuspected and accurate TF-binding site signatures. In this work, we present how such in silico analysis can provide prediction tools to discover new cis/trans relationships… CONTINUE READING

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