Extending the TITE CRM to Multiple Outcomes with Application to a Phase 1 Clinical Trial in Canine Hemangiosarcoma

Abstract

Tables 1 6 present additional simulation results to evaluate the impact of varying π1, the cohort size and the average wating time between subject enrollment. Increasing π1 to 0.10 results in an increased probability of early termination for futility in Scenario 5 and 6 but drastically reduces the probability of correctly identify the optimal dose (Tables 1… (More)

Topics

6 Figures and Tables

Cite this paper

@inproceedings{Koopmeiners2012ExtendingTT, title={Extending the TITE CRM to Multiple Outcomes with Application to a Phase 1 Clinical Trial in Canine Hemangiosarcoma}, author={Joseph S Koopmeiners and Jaime F Modiano}, year={2012} }