Extending Injury- and Disease-Resistant CNS Phenotypes by Repetitive Epigenetic Conditioning

@inproceedings{Gidday2015ExtendingIA,
  title={Extending Injury- and Disease-Resistant CNS Phenotypes by Repetitive Epigenetic Conditioning},
  author={Jeffrey M. Gidday},
  booktitle={Front. Neurol.},
  year={2015}
}
Significant reductions in the extent of acute injury in the CNS can be achieved by exposure to different preconditioning stimuli, but the duration of the induced protective phenotype is typically short-lasting, and thus is deemed as limiting its clinical applicability. Extending the period over which such adaptive epigenetic changes persist - in effect, expanding conditioning's "therapeutic window" - would significantly broaden the potential applications of such a treatment approach in patients… CONTINUE READING
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an overview of experimental and clinical studies

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