Extended therapeutic window for post-exposure treatment of ricin intoxication conferred by the use of high-affinity antibodies.

@article{NoyPorat2017ExtendedTW,
  title={Extended therapeutic window for post-exposure treatment of ricin intoxication conferred by the use of high-affinity antibodies.},
  author={Tal Noy-Porat and Ron Alcalay and Eyal Epstein and Tamar Sabo and Chanoch Kronman and Ohad Mazor},
  journal={Toxicon : official journal of the International Society on Toxinology},
  year={2017},
  volume={127},
  pages={
          100-105
        }
}
The plant toxin ricin is considered a potential bioterror agent against which there is no available antidote. To date, neutralizing antibodies are the most promising post-exposure treatment for ricin intoxication, yet so far they were shown to be effective only when given within several hours post exposure. As part of an ongoing effort to develop efficient ricin-countermeasures, we tested whether high-affinity antibodies that were previously isolated from immunized non-human primates, may… CONTINUE READING
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