Extended therapeutic time window after focal cerebral ischemia by non-competitive inhibition of AMPA receptors.

@article{Elger2006ExtendedTT,
  title={Extended therapeutic time window after focal cerebral ischemia by non-competitive inhibition of AMPA receptors.},
  author={Bernd Elger and Martin Gieseler and Oliver Schmuecker and Ingrid Schumann and Astrid Seltz and Andreas Huth},
  journal={Brain research},
  year={2006},
  volume={1085 1},
  pages={189-94}
}
In acute stroke, the therapeutic time window is a critical factor which may have contributed to the failure of several phase III clinical trials with so-called neuroprotective agents. Since cerebral glutamate levels are elevated for many hours in progressing stroke, we investigated the novel AMPA glutamate receptor antagonist ZK 187638 in rodent models of stroke using up to 12 h delays in the start of therapy after permanent occlusion of the middle cerebral artery (MCA). In rats, ZK 187638… CONTINUE READING
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