Extended studies of the striatal uptake of 99mTc-NC100697 in healthy volunteers.

  title={Extended studies of the striatal uptake of 99mTc-NC100697 in healthy volunteers.},
  author={Walter A. Koch and Oliver Pogarell and Gabriele Poepperl and Julia Hornung and Christine Hamann and Franz-Josef Gildehaus and Klaus Christian Seelos and Dewi W. Lewis and Antonella Favit and Klaus Tatsch},
  journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  volume={48 1},
UNLABELLED This study evaluates a new formulation of a (99m)Tc-labeled tropane derivate, (99m)Tc-NC100697, in a human volunteer study. METHODS Eighty healthy subjects (39 females, 41 males) underwent MRI and SPECT (injected dose [mean +/- SD], 10.6 +/- 1.4 MBq/kg). Forty subjects were investigated 30, 90, 180, 240, 360, and 480 min after injection, and another 40 subjects were imaged 240 min after injection. Specific striatal binding was assessed using 3 different approaches: 3-dimensional… CONTINUE READING
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Dopamine transporter SPECT using fast kinetic ligands : 123 IFP - beta - CIT versus 99 mTc - TRODAT - 1

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