Extended-spectrum plasmid-mediated beta-lactamases.

  title={Extended-spectrum plasmid-mediated beta-lactamases.},
  author={Danielle Sirot},
  journal={The Journal of antimicrobial chemotherapy},
  volume={36 Suppl A},
  • Danielle Sirot
  • Published 1995 in The Journal of antimicrobial chemotherapy
Extended-spectrum beta-lactamases (ESBLs) are mutant enzymes which derive from TEM or SHV (class A) enzymes. They confer variable levels of resistance to cefotaxime, ceftazidime and other broad-spectrum cephalosporins and to monobactams such as aztreonam but have no detectable activity against cephamycins and carbapenems. Recently, new plasmid-mediated ESBLs, not derived from TEM or SHV enzymes but related to cephalosporinases of Enterobacteriaceae (class C enzymes), that confer resistance to… CONTINUE READING


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