Extended-spectrum cephalosporinases in Pseudomonas aeruginosa.

  title={Extended-spectrum cephalosporinases in Pseudomonas aeruginosa.},
  author={J M Rodr{\'i}guez-Mart{\'i}nez and Laurent Poirel and Patrice L. Nordmann},
  journal={Antimicrobial agents and chemotherapy},
  volume={53 5},
The characterization of AmpC-type beta-lactamases was performed in a collection of 32 clinical Pseudomonas aeruginosa isolates with intermediate susceptibility or resistance to imipenem and ceftazidime. Twenty-one out of those 32 isolates overexpressed AmpC beta-lactamase, and the MICs of ceftazidime and imipenem were reduced after cloxacillin addition. Cloning and sequencing identified 10 AmpC beta-lactamase variants. Reduced susceptibility to imipenem, ceftazidime, and cefepime was observed… CONTINUE READING
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Extended-spectrum cephalosporinases in Enterobacteriaceae

  • H. Mammeri, P. Nordmann
  • Anti-Infect. Agents Med
  • 2007

Involvement of the MexXY-OprM efflux system in emergence of cefepime resistance in clinical strains of Pseudomonas aeruginosa

  • D. Hocquet, P. Nordmann, F. El Garch, L. Cabanne, P. Plésiat
  • Antimicrob. Agents Chemother
  • 2006

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