Extended-release tramadol/paracetamol in moderate-to-severe pain: a randomized, placebo-controlled study in patients with acute low back pain.

@article{Lasko2012ExtendedreleaseTI,
  title={Extended-release tramadol/paracetamol in moderate-to-severe pain: a randomized, placebo-controlled study in patients with acute low back pain.},
  author={Ben Lasko and Randy J Levitt and Kim Drummond Rainsford and Sylvie Bouchard and Anna Rozova and Sybil Robertson},
  journal={Current medical research and opinion},
  year={2012},
  volume={28 5},
  pages={847-57}
}
OBJECTIVE Combinations of oral analgesics may offer several potential benefits compared with an individual agent. The objective of this study was to investigate the efficacy and safety of an extended-release, twice-daily fixed combination of 75 mg tramadol/650 mg paracetamol (DDS-06C) in the treatment of moderate-to-severe pain, using acute low back pain as a model. RESEARCH DESIGN AND METHODS In this phase III study, 277 patients with moderate-to-severe acute low back pain were randomized to… CONTINUE READING
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