Extended release lipophilic indomethacin microspheres: formulation factors and mathematical equations fitted drug release rates.

@article{Karasulu2003ExtendedRL,
  title={Extended release lipophilic indomethacin microspheres: formulation factors and mathematical equations fitted drug release rates.},
  author={Ercument Karasulu and H. Yeşim Karasulu and G{\"o}khan Ertan and Levent Kirilmaz and Tamer G{\"u}neri},
  journal={European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences},
  year={2003},
  volume={19 2-3},
  pages={
          99-104
        }
}
  • E. Karasulu, H. Yeşim Karasulu, +2 authors T. Güneri
  • Published 2003
  • Medicine, Chemistry
  • European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
Extended release liphophilic microspheres of indomethacin were prepared using cetostearyl alcohol (CsA), stearyl alcohol (SA) and cetyl alcohol (CA) in the various drug-lipid ratios. The release of indometacin was studied on the basis of USP criteria and the effects of drug-lipid ratio, the size of microspheres and carboxymethylcellulose sodium (CMC-Na) added as a hydrophilic polymer on the drug release were investigated. In vitro dissolution studies were performed using USP XXIII apparatus I… Expand
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