Extended follow-up of the Finnish cartilage-hair hypoplasia cohort confirms high incidence of non-Hodgkin lymphoma and basal cell carcinoma.

@article{Taskinen2008ExtendedFO,
  title={Extended follow-up of the Finnish cartilage-hair hypoplasia cohort confirms high incidence of non-Hodgkin lymphoma and basal cell carcinoma.},
  author={Mervi Taskinen and Annamari Ranki and Eero I Pukkala and Leila Jeskanen and Ilkka I Kaitila and Outi M{\"a}kitie},
  journal={American journal of medical genetics. Part A},
  year={2008},
  volume={146A 18},
  pages={2370-5}
}
Cartilage-hair hypoplasia (CHH) is an autosomal recessive chondrodysplasia with short stature, sparse hair and defective cell-mediated immunity. It is caused by mutations in the RMRP (ribonuclease mitochondrial RNA processing) gene, encoding the RNA component of the ribonuclease complex RNase MRP. The aim of this study was to further elucidate the risk and spectrum of cancer in CHH. A cohort of 123 Finnish patients with CHH (51 males) was followed for malignancy through the Finnish Cancer… CONTINUE READING