Extended culture enhances sensitivity of a gamma interferon assay for latent Mycobacterium tuberculosis infection.

Abstract

To test the hypothesis that prolonged culture would enhance the sensitivity of latent tuberculosis detection by a gamma interferon release assay, blood samples from 33 household contacts of Gambian tuberculosis patients were stimulated with Mycobacterium tuberculosis-specific antigens. After 24 h of culture, 66% were positive, compared to 93% after 6 days of culture.

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Cite this paper

@article{Cehovin2007ExtendedCE, title={Extended culture enhances sensitivity of a gamma interferon assay for latent Mycobacterium tuberculosis infection.}, author={Ana Cehovin and Jacqueline Margaret Cliff and Philip C. Hill and Roger H. Brookes and Hazel M. Dockrell}, journal={Clinical and vaccine immunology : CVI}, year={2007}, volume={14 6}, pages={796-8} }