Extended broad-spectrum beta-lactamases conferring transferable resistance to newer beta-lactam agents in Enterobacteriaceae: hospital prevalence and susceptibility patterns.

@article{Jarlier1988ExtendedBB,
  title={Extended broad-spectrum beta-lactamases conferring transferable resistance to newer beta-lactam agents in Enterobacteriaceae: hospital prevalence and susceptibility patterns.},
  author={V. Jarlier and M. H. Nicolas and G. Fournier and A. Philippon},
  journal={Reviews of infectious diseases},
  year={1988},
  volume={10 4},
  pages={
          867-78
        }
}
  • V. Jarlier, M. H. Nicolas, +1 author A. Philippon
  • Published 1988
  • Medicine
  • Reviews of infectious diseases
  • Before 1985 at the Pitié-Salpêtrière Hospital in Paris (2,400 beds), resistance to cefotaxime in clinical isolates of Enterobacteriaceae involved only species producing inducible class 1 beta-lactamase. Between November 1985 and April 1987, however, 62 isolates (57 of Klebsiella pneumoniae and five of Escherichia coli) showed decreased susceptibility to cefotaxime (mean MIC, 8-16 micrograms/mL). The transferability of cefotaxime resistance in E. coli K12 was demonstrated for 15 of 16 selected… CONTINUE READING
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